Indianapolis, IN 46202Website Place overall summaries in the approach section of each component. Additionally, the application must describe how the components will promote the NAPA research implementation milestones and the goals of NAPA. May be standard or novel biomarkers. Additional Information on Eligibility. Include a data management plan that covers at least the following: Applicants should describe how the Data Management and Statistical Core will fulfill the following required functions, outlining collaborations where applicable: Describe how Data Management and Statistical Core staff, including statisticians, will work with: Demonstrate a clear plan for how the statistical consultant will: Summarize progress and activities related to data collection, data management, and statistical consulting activities. Enter Human Embryonic Stem Cells in each relevant component. Any one investigator is eligible only once for developmental project support, unless the additional proposed developmental project constitutes a real departure from the investigator's ongoing research. Michigan State University, Lansing and Grand RapidsWebsite How strong is the description of the role of and interactions with the Community Advisory Board? 6 Executive Park Drive NE An ADRC will be an identifiable organizational unit formed by a single institution or a consortium of cooperating institutions. Sparks Center, SC 640 4350 Shawnee Mission Parkway Portland, OR 97239-3098Website Describe all non-UDS data to be collected and shared. Describe both database and statistical services that will be provided to each of the components, the Research Education Component, and developmental projects. NIA-designated ADRCs serve as a national resource for research on the nature of Alzheimer's disease (AD) and AD-related dementias (ADRD) and the development of more effective approaches to prevention, diagnosis, care, and therapy. How clear is the description of how the UDS data will be provided in a complete manner to NACC? 1750 W. Harrison, Suite 1000 Social media: Facebook Twitter YouTube Applicants are expected to include Additional Cores appropriate to the theme(s) of the ADRC that both take advantage of local expertise and provide a resource to the broader research community. Clinical Neuroscience Center The University of Texas Health Sciences Center, San AntonioWebsiteDirector's email This includes any recent legislation and policy applicable to awards that is highlighted on this website. Additional Core components which contribute to the overall focus of the Center, are scientifically justified, develop resources that support other research affiliated with the Center, and fit within the budget guidelines outlined in Section II. See more tips for avoiding common errors. Define the samples/biospecimens and other data that will be collected and how their collection will support the aims of the ADRC and other research supported by the ADRC infrastructure. University of Arizona, TucsonWebsite Are all the available Center resources captured and integrated in the system and available for sharing? Have the investigators included plans to address weaknesses in the rigor of prior research that serves as the key support for the proposed project? Faculty must be committed to continue their involvement throughout the total period of this award. The CL should also have experience recruiting understudied and populations relevant to the proposed Center. The administrator must be able to provide consultation in matters of fiscal administration and be familiar with NIH grant-related compliance policies. How strong are the environment and core resources to enhance cutting-edge research by bringing together multidisciplinary investigators? Applicants should describe how they will conduct other major activities of the Outreach, Recruitment, and Engagement Core, which include: Describe past efforts to assist the Clinical Core and NIA special initiatives in participant recruitment, including any efforts directed to recruitment of people from understudied populations and/or those at higher risk for AD/ADRD. Phone: 855-744-0588ADRC email, Wisconsin Alzheimer's Disease Research Center Information line: 833-311-2372ADRC email, Jeffrey Kaye, M.D., Director The research education plans for at least some of the junior faculty and research associates supported through the Research Education Component must provide for the development of combined competence in basic, translational, and clinical research in the areas of AD and ADRD. The CL of this components must commit, and sustain, a minimum of 1.2 person months of effort. Note: The R&R Budget form included in many of the component types allows for up to 100 Senior/Key Persons in section A and 100 Equipment Items in section C prior to using attachments for additional entries. 600 Highland Avenue Phone: 412-692-2700, Satellite Center: View Full Project Details for Roybal Translational Research Center to Promote Context-Specific Caregiving of Community-Dwelling Persons Living with Alzheimer's Disease or Related Disorders Describe the most important contributions to research on AD/ADRD and aging utilizing core resources. An External Advisory Committee (EAC) to conduct and provide annual evaluations of the programs of the ADRC, research sharing and progress, the effectiveness of communications within and outside of the ADRC, interactions with NACC, NCRAD and SCAN, and any other activities for which outside expertise is required or desirable. Although each center has its own area of emphasis, the ADRCs also enhance research on Alzheimers disease as a network that shares new research ideas and approaches as well as data (through the National Alzheimers Coordinating Center), biological samples (through NCRAD) and genetic information (through ADGC). The ADRCs provide a mechanism for fostering and coordinating the interdisciplinary cooperation of a group of established investigators conducting programs of research on AD/ADRD. How well does the Biomarker Core interact with other components to contribute to the goals of the ADRC as well as the national efforts of the ADRC program? 114 16th Street, #2011 Does the proposed program address a key audience and an important aspect or important need in research education? Information line: 508-322-0875ADRC email Phone: 210-450-9960 or 210-258-4605, University of Washington Alzheimer's Disease Research Center Applications will be evaluated for scientific and technical merit by (an) appropriate Scientific Review Group(s) convened by NIA, in accordance with NIH peer review policy and procedures, using the stated review criteria. In order to maximize the availability and usability of the data and research resources generated by NIAs ADRC program, and to comply with the NIH Genomic Data Sharing Policy and the NIA/NIH efforts aimed at increasing transparency, reproducibility, and translatability of research findings, the awardees are expected to engage in broad sharing of data and biological samples, analytical methodology, and disease models prior to publication, consistent with achieving the goals of the program. Program Directors/Principal Investigators (PD(s)/PI(s)). Describe the criteria used to appoint and remove individuals as program faculty and to evaluate their participation. The leadership team should also have experience in evaluation, as it is critical to assess effectiveness of outreach/engagement programs. Describe how outside investigators will have access to the Center's samples and view the catalog of biospecimens for the proposed ADRC. Obtaining an eRA Commons account can take up to 2 weeks. 1101 Yale NE Manage the biospecimen collection of the Center and coordinate catalogs of available samples with NACC. Taking into consideration the nature of the proposed research education program, does the applicant make a strong case for this program effectively reaching an audience in need of the programs offerings? The law calls for a National Plan to address AD/ADRD. Care research: research on formal or informal care partners, facilitate validation of care models, including palliative care and end-of-life care, particularly to take advantage of unique opportunities locally or nationally, such as healthcare policy changes,unique care resources, Implementation and dissemination: access well-coordinated community-based healthcare systems and clinics to expedite conduct of studies enabling evaluation of evidence-based research findings in clinical practice, Administrative data: supplement ongoing data collection with administrative data sets, e.g., consent study participants to allow linkages of current data with electronic health records (EHRs), Social Security Administrative data, Center for Medicare and Medicaid (CMS) and/or Veterans Affairs (VA) claims data. For applications with multiple CLs, a minimum effort of 0.8 person-month is required per additional Core Leader. Provide an environment and resources to enhance cutting-edge research by bringing together investigators from various fields to study the etiology, pathogenesis, diagnosis, treatment, and prevention of AD/ADRD. If a Changed/Corrected application is submitted after the deadline, the application will be considered late. Information line: 415-476-3722ADRC emailDirector's email, Helena Chui, M.D., Director Appealsof initial peer review will not be accepted for applications submitted in response to this FOA. Florida Atlantic University, Boca RatonWebsite Vanderbilt Exploratory Alzheimers Disease Research Center Is a refinement, improvement, or new application of theoretical concepts, approaches or methodologies, instrumentation, or interventions proposed? Wake Forest Baptist Medical Center How well does the core serve as a community resource? We are on a mission to modernize data collection, integration, and sharing to advance Alzheimer's research. Centers must also agree to image participants with a standardized protocol managed by the Standardized Centralized Alzheimers & Related Dementias Neuroimaging (SCAN) infrastructure. New applications: Describe preliminary organizational work, institutional experience with AD and other neurodegenerative disease research, potential for developing transformative research, and specific plans for implementation of the new program. Information line: 212-263-8088 University of Wisconsin 2nd Floor Box 359791 Social media: Instagram Twitter The applicant organization must ensure that the unique entity identifier provided on the application is the same identifier used in the organizations profile in the eRA Commons and for the System for Award Management. What does the developmental projects and the plan for developmental projects accomplish for the Center? The Federal Funding Accountability and Transparency Act of 2006 (Transparency Act), includes a requirement for recipients of Federal grants to report information about first-tier subawards and executive compensation under Federal assistance awards issued in FY2011 or later. Research education support should be integrated with other sources of career support that they may be receiving (e.g., career awards (NIH or not), fellowships) in concerted programs for research education. Include a description of how the Outreach, Recruitment, and Engagement Core will enhance recruitment and retention of volunteers into AD and ADRD research, including clinical trials. Conformance to all requirements (both in the Application Guide and the FOA) is required and strictly enforced. The Alzheimer's Disease Research Center (ADRC) at Wake Forest School of Medicine brings together the latest technologies in neuroscience, neuropsychology, brain imaging and new treatmentsall helping to find new ways to slow brain aging. The committee will evaluate the involvement of live vertebrate animals as part of the scientific assessment according to the following criteria: (1) description of proposed procedures involving animals, including species, strains, ages, sex, and total number to be used; (2) justifications for the use of animals versus alternative models and for the appropriateness of the species proposed; (3) interventions to minimize discomfort, distress, pain and injury; and (4) justification for euthanasia method if NOT consistent with the AVMA Guidelines for the Euthanasia of Animals. Describe complementary expertise and experiences of the proposed program faculty, including active research and other scholarly activities in which the faculty are engaged, particularly interdisciplinary work, as well as experience mentoring and training individuals at the proposed career stage(s). Mass General Hospital They create shared resources that support dementia-relevant research, and they collaborate and coordinate their research efforts with other NIH-funded programs and investigators. The National Institute on Aging (NIA) at the National Institutes of Health (NIH) funds more than 30 ADRCs at medical institutions across the country. Paper applications will not be accepted. This means that the NIH will not accept: The application forms package specific to this opportunity must be accessed through ASSIST or an institutional system-to-system solution. Join a clinical trial and be part of the breakthrough! Alzheimer's Disease Research Center Neuropathologists from the ADRCs meet yearly to share ideas and discuss technical aspects of tissue sampling, development of standardized tissue processing for various research protocols, cataloging and data management, and banking and distribution of tissues and biological samples. Research Strategy: Organize the Research Strategy into the following sections: Significance, Innovation, and Approach. Applications must include a PEDP submitted as Other Project Information as an attachment. Applications must be submitted electronically following the instructions described in the SF424 (R&R) Application Guide. Funding Opportunity Description, Section IV. To what extent will data be available in a useful format for both planned and future analyses? Characterized abnormal proteins associated with several different neurodegenerative diseases. The goal of the Johns Hopkins Alzheimer's Disease Research Center (ADRC) is to accelerate the discovery of new treatments that are directed at the basic mechanisms of disease, and to hasten the time when effective treatments for AD and related disorders become a reality. Information line: 904-953-6523. Describe how the prioritization will be used to support specific research efforts of investigators affiliated with the local Center and other scientists. Where possible, applicant(s) should align their description with these required elements within the research strategy section. 1750 W. Harrison, Suite 1000 Coordination with NIA on media coverage of the latest research findings from the Center. Registration can take 6 weeks or more, so applicants should begin the registration process as soon as possible. Basic functions of the core should be briefly summarized. Recruitment Plan to Enhance Diversity: Fostering diversity in the scientific research workforce is a key component of the NIH strategy to identify, develop, support, and maintain the quality of our scientific human capital (NOT-OD-20-031). Arizona State University, Phoenix and Tempe Use the hashtag #NIAfundedADRC to tag and find ADRC news. Before sharing sensitive information, make sure youre on a federal government site. Other Information for award authorities and regulations. Information line: 855-744-0588ADRC email, Sanjay Asthana, M.D., Director Highlight efforts to modernize, where applicable, and standardize electronic data capture (EDC) and database structure across ADRCs to augment Center-NACC, Center-Center, and Center-NIH interactions. This FOA does not require cost sharing as defined in the NIH Grants Policy Statement. Plan to utilize the project infrastructure (i.e., research and structure) to support career-enhancing research opportunities for diverse junior, early- and mid-career researchers. Alzheimer's Disease Research Center Mount Sinai School of Medicine As applicable for the component proposed, reviewers will evaluate the following additional items while determining scientific and technical merit and in providing an overall impact score but will not give separate scores for these items. Director's phone: 650-723-6469, Charles S. DeCarli, M.D., Director A full list of policy notices published by NIH is provided in the NIH Guide for Grants and Contracts. Specific Aims: Clearly describe how the Biomarker Core will contribute to the goals of the ADRC and outline interactions between the core and each component of the Center. Florida International University, Miami Describe the most important contributions to research on AD/ADRD and aging utilizing Neuropathology Core resources. Is there a plan to take advantage of this environment to enhance the educational value of the program? Are the plans for communicating the latest research findings to the public sufficient? Feinberg School of Medicine Program Director:Nina Silverberg, Ph.D. Identified factors that contribute to changes in cognitive abilities, such as social and physical activity. The Diverse Vascular Cognitive Impairment and Dementia study (VCID) is the first large study to address the question of how white matter lesions found on MRIs impact memory and thinking . Although CC participants should be prioritized, clear plans to obtain additional autopsies on other people that may enhance the overall scientific endeavor may be included. Does the application challenge and seek to shift current research or clinical practice paradigms by utilizing novel theoretical concepts, approaches or methodologies, instrumentation, or interventions? Find information on funding, program contacts, and news about the ADRCs. Pittsburgh, PA 15213Website Describe how the Center will provide information and resources to the local community as well as more broadly. For these terms of award, see the NIH Grants Policy Statement Part II: Terms and Conditions of NIH Grant Awards, Subpart A: General and Part II: Terms and Conditions of NIH Grant Awards, Subpart B: Terms and Conditions for Specific Types of Grants, Recipients, and Activities, including of note, but not limited to: If a recipient is successful and receives a Notice of Award, in accepting the award, the recipient agrees that any activities under the award are subject to all provisions currently in effect or implemented during the period of the award, other Department regulations and policies in effect at the time of the award, and applicable statutory provisions. Mount Sinai Medical Center, Miami Beach Harborview Medical Center The center is proud to be one of 12 Alzheimer's Disease Research Centers participating in a new and exciting study led by the University of California, Davis. New applications: In addition to the above, describe preliminary organizational work; institutional experience with recruitment, engagement, and outreach for AD and other neurodegenerative disease research; potential for developing or contributing to new and exciting methods; and specific plans for implementation of the new program. NIA-funded Alzheimer's Disease Research Centers (ADRCs) work to translate research advances into improved diagnosis and care, as well as find ways to treat and possibly prevent Alzheimer's disease and related dementias in all people. How well are data from the biomarkers connected with other relevant ADRC data? Specific Aims: Clearly describe how the Outreach, Recruitment, and Engagement Core will contribute to the goals of the ADRC and outline interactions of the core with each of the other components of the Center. PHS Human Subjects and Clinical Trials Information (Administrative Core). 300 E. Superior Street, Tarry 8 Medical Center Boulevard Project /Performance Site Location(s) (Neuropathology Core), Research & Related Senior/Key Person Profile (Neuropathology Core), PHS 398 Research Plan (Neuropathology Core). Journey to Hope - November 12, 2022 A conference event on the diagnosis and treatment of memory loss as well as tips to manage Alzheimer's disease and its associated behaviors. Sacramento, CA 95817-4540Website New applicants should contact NACC to learn more about NACC procedures, the structure of the UDS, and the regular updates to the data sets required from all Centers. Describe demographic information, including numbers of participants recruited, diagnosis, relevant risk factors, percentage follow up, dropout rate and reasons for drop out, and diagnostic accuracy confirmation by autopsy. Portland, OR 97239-3098Website This initiative is not subject to intergovernmental review. For patients and families affected by Alzheimer's disease or a related dementia, the ADRC at Mayo Clinic offers education and support . This content is provided by the National Institute on Aging (NIA), Innovation: Describe novel aspects of the proposed Outreach, Recruitment, and Engagement Core. Palo Alto, CA 94305Website Project Summary/Abstract: Briefly describe the mission, vision, and research goals of the Center for the next five years and describe how these have been integrated into the research programs specific goals. Describe how the Data Management and Statistical Core will use current data analytic and bioinformatics technologies to collect, analyze, and integrate data from across the ADRC. Approach and Innovation: State how the system infrastructure will improve data capture and provide accurate, timely data about the resources of the Center across all relevant cores. Find Alzheimer's research centers that provide diagnosis, medical research, and support groups. Create an environment that supports innovative multidisciplinary, inclusive research that has a significant impact on the field of dementia research and treatment; Foster interdisciplinary collaborations, especially in emerging areas of research, to catalyze new ideas and scientific approaches; Attract, educate and/or train, and retain a group of early stage investigators and investigators new to dementia research that is richly diverse in backgrounds, and academic and technical disciplines; Translate scientific discoveries from bench to bedside to community that improve public health and include validation and effectiveness measures; Provide rapid and broad sharing of analytic and research tools, as well as data, as appropriate and as consistent with achieving the goals of the program; and. If such cases are planned, describe how they will be obtained and ensure that the samples and data can be made available to the wider research community. If the aims of the project are achieved, how will scientific knowledge, technical capability, and/or clinical practice be improved? PHS Human Subjects and Clinical Trials Information (Biomarker Core), Research Education Component - Linked Education Project (RL5), When preparing your application, use Component Type Research Education., SF424 (R&R) Cover (Research Education Component (RL5)), PHS 398 Cover Page Supplement (Research Education Component (RL5)), Research & Related Other Project Information (Research Education Component (RL5)), Project /Performance Site Location(s) (Research Education Component (RL5)), Research & Related Senior/Key Person Profile, Budget (Research Education Component (RL5)), PHS 398 Research Plan (Research Education Component (RL5)). , Miami describe the criteria used to support specific research efforts of investigators affiliated with community. 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